Molecular Diagnosis & Gene Therapy BIPH 4248

Course description:

This course aims to survey the basic principles of molecular biology and examine their
Relevance to the identification of disease-causing genes/mutations and the diagnosis of human genetic disorders. 
The molecular basis of gene therapy and the use of viral gene delivery systems for the treatment of human disease are examined. Gene therapy strategies are contrasted with various diseases, including cancer and AIDS.

Course Aims:

Upon successful completion of this course, participants will be able to:
  • Describe the structural organization of the human genome, starting from the basic molecules that comprise the genetic material and expanding to the overall organization of chromosomes.
  • Examine and understand modern tools employed to study DNA structure, identify variations in structure among individuals, and apply this information to determine the molecular basis of human diseases. 
  • We will also survey recent literature to obtain information about latest technological advances and diagnostic applications, and discuss the future prospects for molecular approaches to disease diagnosis.

Course outcomes:

Upon successful completion of this course students will be able to:  
  • Become familiar with basic molecular techniques.
  • Understand gene mapping and linkage analysis.
  • Become conversant with the goals and accomplishments of the Human Genome Project.
  • Recognize the importance of molecular methods in disease and forensic diagnosis.
  • Knowledgeof diagnostic approaches for common genetic disorders
  • Comprehendthe different types of gene delivery systems and
  • Demonstrate how gene therapy can be used to treat human disease.