Pharmaceutical Chemistry 3 BIPH 4231

Course description:

This course covers the synthesis, structure-activity relationship, metabolic pathways of drugs, including central nervous system stimulants and depressants. The practical course includes some the respective analytical procedures. Special analytical methods described in pharmacopoeias (tests for identity and purity control of the pharmaceutical compounds) and validation of the results.

Course Aims:

Describe the theoretical aspects related to agents adopted for the treatment of various cardiovascular and central nervous system (CNS) disorders e.g. antihypertensive agents, anti-angina agents, anti-arrhythmias, CNS stimulants and CNS depressants. 
Describe the chemical and biological properties of such class of compounds, structure activity relationships, molecular modes of action, and methods of synthesis, purification as well as their principles of analysis.

Course outcomes:

Upon successful completion of this course students will be able to:  
  • Illustrate the specific pathways of drug metabolism. 
  • Recognize the theoretical concepts and methodology of different principles of drug design (Structure-based/ Ligand-based). 
  • Recognize the activity & toxicity profile of various drugs, deduced from their structure & metabolism. 
  • Identify the various properties of the studied drug classes, including mechanisms of actions, therapeutic uses, dosage, contra-indications and drug interactions. 
  • Specify the properties of medicinal substances and their relation to chemical structure including the relationship between physicochemical properties and activity of various drugs.