Pharmaceutical Chemistry 1 BIPH 3221

Course description:

The course gives the student basic knowledge of understanding the chemistry (as well as introduction to pharmaceutical chemistry, the history of drugs, drug sources, nomenclature and Classification, Physicochemical properties: Solubility of drugs.
The course gives covers also Chemical properties: Chemical bonding in drug and receptor interactions, Steric factors, Drug metabolism: Phase I reactions, Drug metabolism: Phase II reactions, Structure-activity relationships, New drug development, Designing and synthesis.

Course Aims:

  • Provide students with a complex understanding of drug chemistry.
  • Study the drugs from the point of view of their rational selection and preparation, quality criteria, structure-affinity/activity- and structure metabolism relationships yielding a certain pharmacodynamics /pharmacokinetic as well as therapeutic profile.
  • Introduce drug discovery and development, physicochemical properties of drug-like molecules, ligand-receptor interactions, drug metabolism, pharmacokinetics, and pharmacodynamics, selected specific therapeutic groups.

Course outcomes:

Upon successful completion of this course students will be able to:  
  • Describe the role and objectives of Pharmaceutical/Medicinal Chemistry within Pharmaceutical Sciences. 
  • Recognize the physicochemical properties of different drug molecules based on knowing the typical functional groups present in drug molecules. 
  • Define different phases of drug discovery and development, know different sources of lead compounds, and understand the prodrug concept for drug development. 
  • Define and understand the pharmaceutical, pharmacokinetic, and pharmacodynamics phase of drug action, therapeutic use, and adverse effects. 
  • Describe the differences between phase I, II, and III of clinical trials, and know the criteria for drugs approval.