Pharmaceutical Organic Chemistry 2 BIPH 2318

Course description:

This course is a continuation  of Pharmaceutical Organic Chemistry 1 , it covers the aromatic compounds – Benzene, structure and reactivity, Aromaticity, Nomenclature, Electrophilic Aromatic Substitution and their mechanism, The Friedel–Crafts Alkylation and Acylation, Nucleophilic reactions. Aldehydes and Ketones, structure, reactivity, nomenclature, Nucleophilic addition of hydride, formation of hydrates and acetals, formation of thioacetals, formation of imines and enamines, a-Substitution reactions, Keto-enol tautomerism, Reactivity of enols, Acidity of -hydrogen atoms: enolate ion formation, the aldol condensation reaction. carboxylic acids and derivative; structure, reactivity and nomenclature, Nucleophilic substitution reactions of carboxylic acids, -Substitution reactions of carboxylic acid. The Claisen condensation reaction.  Amines, structure, reactivity, nomenclature, biological importance of amines and their reactions. Heterocyclic  compounds 5 and 6 member ring, such as pyridine, pyrrole, furan and thiophene, imidazole, oxazole, diazines, pyrazole, isoxazole, synthesis of some 5 and 6 member ring.

Course Aims:

The main goal of this course is to provide student with:
  • The concept of aromaticity, difference between aromatic and nonaromatic compound, benzene, the electrophilic substitution reactions of benzene their mechanism and some major reaction of aromatic compounds. 
  • Aldehydes and ketones and their complete chemistry. Know Carboxylic acids and their derivatives, their reactivity and reactions. 
  • Amines and their chemistry and biological importance. 
  • Introduce student for Heterocyclic chemistry and the different groups of this family and their use in pharmaceutical industry.

Course outcomes:

Upon completion of this course, the student should be able to:
  • Understand aromaticity and differentiate between aromatic and non-aromatic compounds.
  • Understand the different reactions of aromatic compounds
  • Electrophilic Substitution reactions
  • Know aldehydes and ketones the chemical difference between them their physical and chemical properties.
  • Describe Keto-enol tautomerism, Reactivity of enols, Acidity of a-hydrogen atoms: enolate ion formation, the aldol condensation reaction. 
  • Understand Carboxylic Acids and their reactivity and complete chemistry.
  • Know Nucleophilic substitution reactions of carboxylic acids.
  • Understand Amines, structure, reactivity, nomenclature, biological importance of amines and their reactions.
  • Discuss Heterocyclic  compounds 5 and 6 member ring, such as pyridine, pyrrole, furan and thiophene, imidazole, oxazole, diazines, pyrazole, isoxazole, synthesis of some 5 and 6 member ring.